ABSTRACT
Objective To explore the correlations of lung resistance protein (LRP) and glutathione S transferase π (GST-π) to chemotherapy resistance and prognosis of epithelial ovarian cancer.Methods The expressions of LRP and GST-π in epithelial ovarian cancer were examined with immunohistochemistry.Correlations of LRP and GST-π to chemotherapy efficacy and survival time after operation were analyzed.Results The short-term efficacy rates of ovarian cancer were lower in patients with positive expressions of LRP and GST-π than those with negative expressions [61.2%,61.7% vs 94.1%,89.5%,x2 =6.47,4.94,P =0.011,P =0.026].The positive rates of LRP and GST-π were significant higher in patients with chemotherapy resistance than in those sensitive to chemotherapy [91.3%,87.0% vs 65.1%,62.8%,P < 0.05].Log-rank test showed that patients with positive LRP and GST-π had shorter survival time than those negative,and patients with both positive LRP and GST-π had shorter survival time than those both negative (P < 0.05).Conclusions The expressions of LRP and GST-π in epithelial ovarian cancer could be used to predict chemotherapy resistance and prognosis of patients.
ABSTRACT
This paper reviewed the academic contribution of famous doctor of traditional Chinese medicine belonging to Yishui sects, and analyzed the change of chronic non-communicable disease in the 21st century. On this basis, the paper put forward that we should exert the advantages of traditional Chinese medicine, explore the regularity of treating chronic non-communicable disease, refresh the academic innovation, and generate new ideas and new treatment.
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This paper analyze the dynamic observation results ofCD4+ and CD8+ T lymph cell of13 cases HIV/AIDS patients, who have survived for more than ten years.The analysis show that long term Chinese medicine intervention have effect in increasing and maintaining CD4+ T lymph cell, and activating or adjusting CD8+ lymph cell.Chinese medicine also has the effect in delaying the progression ofAIDS and prolonging longevity.